eggroup sector dermocosmetico perfumeria

veda active forskohlin



Veda active and the Ayurveda
The word ayurveda has its root in two Sanskrit words: Ayur, "Ayuso" which means longevity and Veda, "ved or veda" which means science and ayurveda is the science of rejuvenation and restoration of health.

It is regarded as a genuine system of life to promote health and has its origins in India over 5,000 years ago. The Ayurvedic pharmacopoeia contains over 5,000 different formulations that have been developed over millennia.

VEDA ACTIVE is a line of plant extracts based on the ancient Ayurvedic medicine but with today’s technology. Extracts with extreme purity in active ingredients.


Composition and molecular structure
The main active of Coleus forskohlii is forskolin. It belongs to the group of triterpenic labdanes with a big impact on cellular processes led by cAMP.

forskohlin


Mechanism of action
Adenil-cyclase activation: The basis of the mechanism of action of Forskohlin is activation of an enzyme, adenil-cyclase, which increases cAMP in the cells. Furthermore, it acts as a by-pass in the process of direct hormonal activation of the adenil-cyclase.

forskohlin
FL Greenway, GA Bray and D Heber Department of Medicine, UCLA School of Medicine, Torrance, CA, USA. Topical fat reduction Obesity Research 3:561S-568S (1995)


Effectiveness
• In vitro lipolytic activity: fat cells and lipolytic agents (forskohlin among them) were incubated together with hormone-sensitive lipase (HSL). The table below shows the effects.

• Fat Reducer: A double-blind study with obese women, topically applied product. It is divided into 5 groups, each group with an active. Forskohlin was tested in group 2 and 3. The results showed an important reduction in the circumference of the thigh.

TABLE 1. Effects of various lipolytic agents on HSL (hormone-sensitive lipase)
forskohlin
Morimoto et al. Lipolytic agents and lipólisis. Relationships between lipólisis induced by various lipolytic agents and hormona-sensitive lipase in rat fat cells.


Applications
• Lipolytic action: lipolysis is a process largely governed by cAMP. It has been shown that Forskohlin significantly stimulates lipolysis as well as inhibition of adenosine and thus preventing fat synthesis in adipocytes.

• Protection from UV: Recent studies published by Nature show that Forskohlin is an activator of melanin without sunlight.

• Activity against psoriasis and atopic dermatitis: Psoriasis is characterized by low levels of cAMP in the skin related to GMP (guanosine monophosphate Ciclasa) levels. The ability of forskohlin to regulate levels of cAMP in skin cells has proved to have a therapeutic benefit to combat psoriasis.


Inci name: Veda active forskohlii extract
Purity: 95% forskohlin
Dosage: 0.05 to 0.1%